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    Imiquimod 5-Percent Cream Does Not Alter the Natural History of ...

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    or matching placebo cream) at bedtime (to achieve topical treatment for approximately 8 to 10 h per application) according ... Swabs for HSV culture and/ or PCR were obtained at the clinic for each ...

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    The fisher exact test was used to compare the proportions of patients who were recurrence free and the incidence of adverse events across treatment arms. Documentation of a prior clinical diagnosis or of hsv-2 seropositivity was required. There is no posttreatment efficacy discontinuation of suppressive treatment results in reversion to the pretreatment recurrence rate ( an alternative strategy for control of hsv disease is to enhance the hosts ability to control the virus.

    Of 235 patients screened, 209 entered the 12-week eligibility period and 124 had a qualifying recurrence to be randomized to treatment. However, as some of the cytokines induced by imiquimod have proinflammatory properties, application in the presence of lesions may also increase the inflammatory response. More patients in the groups receiving imiquimod two times per week (22) and three times per week (25) than patients in the group receiving imiquimod once per week (12) or placebo (13) reported adverse events that were considered possibly or probably related to the study medication however, the differences were not statistically significant, and no trends were observed when the adverse events were analyzed by body system terms, including application-site reactions.

    Twenty-one patients (17) discontinued from treatment during the treatment period however, three of these patients continued into the observation period. Posttherapy suppression of genital herpes simplex virus (hsv) recurrences and enhancement of hsv-specific t-cell memory by imiquimod in guinea pigs. Figure provides a comparison of moderate or severe maximum local skin signs by treatment group.

    During follow-up, 60 (75) of the 80 female patients had vulvar lesions and 16 (20) had perineal lesions. The median time to the next recurrence after the initial treated recurrence in this study for the imiquimod groups combined was 56 days, nearly identical to that for the placebo group in this study (53 days) and to that in the resiquimod study (57 days). Overall, 110 of the 124 randomized patients (89) had an hsv culture- or pcr-positive recurrence at some time during the study.

    A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections. In this study of topical application of imiquimod to lesions of recurrent herpes genitalis, no evidence of posttreatment efficacy was observed with respect to increasing the time to the next recurrence or decreasing the total number of recurrences in either period. In addition, as a species guinea pigs may also be more sensitive to manipulation of the hsv immune response than humans, and other immune-based therapies with evidence of efficacy in this model have failed to be confirmed in studies with humans ( these results are in contrast to those observed in a phase ii study involving a related immune response modifier, resiquimod, with a similar patient population ( ) also observed a trend toward increased local adverse events associated with more frequent dosing and higher concentrations of resiquimod gel during the latter portion of a 3-week treatment course.

    There did not appear to be a difference across treatment groups with respect to discontinuations during the treatment or the observation period. Safety was determined by clinical laboratory measurements, collection of information regarding adverse events, and lesion assessments (the number of lesions and the size, location, and stage of each lesion). All statistical tests, other than efficacy analyses, were two tailed at a significance level of 0. This was despite evidence of pharmacologic activity, as manifested by the non-statistically significant increases in local adverse events associated with more frequent imiquimod dosing. Investigator-confirmed recurrences were defined as those that were visually verified in the clinic.


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    Dermatol Online J. 2006 Mar 30;12(3):10. Treatment of invasive squamous cell carcinoma with 5-percent imiquimod cream. Konstantopoulou M(1), Lord MG, ...

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    Includes Aldara side effects, interactions and indications. ... When treating genital warts around the vagina, avoid getting the cream on the more sensitive inner layers of ... Use the medicine before going to bed and leave it on for 8 hours.
    Buy now Aldara 5percent 8 creams in Ventura The median times to the next patient-reported recurrence after the initial treated recurrence were 53 days for patients receiving placebo and 54, 60, and 64 days for patients receiving imiquimod at one, two, and three times per week, respectively (fig. Kaplan-meier estimate of time to first patient-reported recurrence for each treatment group after the first treated recurrence in the treatment period. More than 20 of adults in the united states are infected with hsv-2, Overall. Because hsv is capable of establishing latency in the sensory ganglion, intermittent reactivation of viral replication can result in both symptomatic and subclinical recurrences, Although clinical efficacy has been observed for imiquimod in other conditions in which a th1-type immune response may be beneficial, including other viral infections such as those caused by human papillomavirus. Subclinical reactivations are also variable, It was hypothesized that application of imiquimod to herpes lesions would induce ifn- and il-12 in the skin, which, in the presence of hsv antigens present during a recurrence. The goal of this study was to determine if topical imiquimod 5 cream, which has evidence of clinical efficacy against genital human papillomavirus infections, would provide a similar benefit for another viral infection, recurrent herpes genitalis, Squamous cell carcinoma (scc).
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    These parameters were analyzed for any patient-reported recurrence (primary endpoint), investigator-confirmed recurrence, and virologically confirmed recurrence. In addition, fewer patients in the groups receiving imiquimod two times per week (22) and three times per week (22) than patients in the group receiving imiquimod one time per week (55) or placebo (43) were healed by day 8. Hsv western blotting was performed by the university of washington, seattle ( the primary efficacy parameter was the time to recurrence following treatment. Twenty-one patients (17) discontinued from treatment during the treatment period however, three of these patients continued into the observation period. Analysis of the maximum severity of each defined local sign and symptom, about which information was collected separately from information on the other adverse events, during the initially treated recurrence did not show differences or trends across treatment groups.

    Comparison of western blot (immunoblot) and glycoprotein g-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. Enrollment began in november 1998, and all study procedures were completed by july 2000. The hypothesis that combining an immune-response modifier with host-provided hsv antigen, a form of therapeutic vaccination, might control hsv recurrences may still prove valid in future studies with resiquimod. In addition, resiquimod appears to be more effective in activating dendritic cells, which may be crucial in hsv antigen presentation in the skin ( despite evidence of some pharmacologic response, imiquimod 5 cream, dosed in the regimens studied, did not reduce the number of subsequent herpes recurrences or prolong the interval between recurrences. For each recurrence during the treatment period, the patients applied study cream (imiquimod 5 cream aldara 3m pharmaceuticals, st.

    The median number of recurrences of herpes genitalis in the past year was 8 (range, 0 to 20 recurrences), and 11 of patients reported having been on oral suppressive therapy prior to study entry. In contrast, administration for 3 weeks resulted in a continued reduction in lesion formation posttreatment. Although clinical efficacy has been observed for imiquimod in other conditions in which a th1-type immune response may be beneficial, including other viral infections such as those caused by human papillomavirus, no apparent effect on the short-term natural history of herpes genitalis recurrences was observed. All statistical tests, other than efficacy analyses, were two tailed at a significance level of 0. E-mail members of the imiquimod herpes simplex virus (1330-imiq) study group follow timothy schacker, university of minnesota, minneapolis, minn. Recurrences that had a positive hsv culture or pcr result were defined as virologically confirmed. Overall, topical application of imiquimod to genital herpes lesions was reasonably well tolerated. The proportions of patients who were recurrence free at the end of the treatment period were 10 for the placebo group and 24, 25, and 21 for the patients receiving imiquimod at one, two, and three times per week, respectively this was not statistically significant. Cell-mediated immunity (cmi) is believed to play a major, if not well-understood, role in restricting reactivations ( suppression of genital herpes recurrences focuses on use of nucleoside analogs, such as acyclovir, valacyclovir, and famciclovir, which inhibit viral replication by interfering with hsv dna polymerase ( ). There were no statistically significant differences in the time to first recurrence or in the annualized recurrence rate between the imiquimod and placebo groups in either the treatment or the observation period.

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    Apply imiquimod cream for 6 weeks, 5 times per week (example: Monday to Friday) prior to normal sleeping hours, and leave on the skin for approximately 8  ...
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